Theories Cognitive Psychology How to Prevent Brain Shrinkage With Age It is possible to reduce age-related brain atrophy and shrinkage By Kendra Cherry, MSEd Kendra Cherry, MSEd Kendra Cherry, MS, is a psychosocial rehabilitation specialist, psychology educator, and author of the "Everything Psychology Book." Learn about our editorial process Updated on January 29, 2024 Medically reviewed Verywell Mind articles are reviewed by board-certified physicians and mental healthcare professionals. Medical Reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more. by Shaheen Lakhan, MD, PhD, FAAN Medically reviewed by Shaheen Lakhan, MD, PhD, FAAN Shaheen Lakhan, MD, PhD, is an award-winning physician-scientist and clinical development specialist. Learn about our Medical Review Board Print Hero Images / Getty Images Table of Contents View All Table of Contents Effects Causes Prevention Trending Videos Close this video player Just as the body gets older, so does the brain. One of the natural effects of aging is a shrinking brain. Some brain regions tend to shrink more than others, with age-related shrinkage in certain regions being more variable, differing from one person to the next. Here we explore what happens when the brain shrinks, as well as factors that could contribute to this effect. We also share a few steps that, when taken, can help reduce a shrinking brain with age. Effects of a Shrinking Brain Brain shrinkage can play a role in age-related declines in cognitive abilities. As they get older, people may experience a reduction in their abilities related to: Episodic and working memory Processing speed Spatial reasoning Brain shrinkage is sometimes referred to as cerebral atrophy or brain atrophy. Atrophy refers to a loss of cells. When this loss occurs within the brain, it means a loss of neurons and their connectors. A reduction in brain connectivity can lead to delirium, which is more common in elderly patients than their younger counterparts, even potentially progressing to dementia. Thus, finding ways to counteract this effect may help preserve cognitive function later in life. Other aging-related brain changes can include: Decreases in brain mass Loss of connections between neurons Changes in the neurotransmitter systems that communicate information in the brain and body Neurons and Their Role in the Nervous System Brain Shrinkage Causes What causes the brain to shrink or atrophy as we get older? There are a couple of factors to consider. Low Fitness Levels Researchers from the Boston University School of Medicine found that people with poor physical fitness in their 40s have significantly lower brain volumes by the time they reach age 60. Experts consider this decrease in brain volume a sign of accelerated brain aging. The study reviewed exercise data from more than 1,200 adults who were around the age of 40, all of whom were part of the larger Framingham Heart Study. When these participants were given MRI scans 20 years later, those who were less fit in midlife had much lower levels of brain tissue later on. Other studies echo the findings that being physically fit early in life (around age 25) leads to better cognitive performance in middle age. Vascular Damage The researchers from Boston University also found that people with low fitness levels had a much higher rise in diastolic blood pressure after just a few minutes on a treadmill, even when moving at a slow pace. It was these people who were more likely to have reduced brain volume at age 60. Fluctuations in blood pressure can damage small vessels in the brain that are vulnerable to such changes. Vascular damage in the brain can then contribute to structural changes and cognitive losses. The researchers in this study were interested in looking at how these dramatic blood pressure changes could contribute to future brain structure changes. They found that those who had lower fitness levels in midlife did worse on cognitive tests at age 60 than those who had been fit during their 40s. Additional Brain Shrinkage Causes Other non-age-related causes of brain shrinkage include injury, certain diseases and disorders, and infections. Brain shrinkage can also be caused by alcohol use. How to Prevent a Shrinking Brain With Age While some causes of brain shrinkage may not be avoidable, there is evidence that certain lifestyle changes may help protect the brain from age-based declines. Get Regular Exercise Regular exercise can help protect the brain from shrinkage as people grow older. The Physical Activity Guidelines for Americans recommends that most people get a minimum of 150 minutes of heart rate-raising activity per week, along with a couple of days of some type of strength training. However, any amount of movement can help. There are plenty of great reasons to get and stay physically fit. Aside from being protective against brain atrophy, regular exercise has been shown to improve cognitive functioning. It's also good for one's physical health and provides mental health benefits as well. Control Blood Pressure Another way to protect against brain shrinkage is to control one's blood pressure to reduce the risk of vascular damage. Regular exercise can help with this. It's also beneficial to take the time to reduce stress, limit the amount of salt consumed, and strive to maintain a healthy weight. Individuals who have trouble controlling their blood pressure on their own should speak with their healthcare provider. This provider may recommend medications to keep blood pressure at a healthier level for the body and brain. Can Anxiety Cause High Blood Pressure? Make Other Lifestyle Changes In addition to exercise and blood pressure stabilization, there are a few other activities that research suggests may help reduce age-related brain declines. They include: Avoiding or quitting smoking Eating a healthy diet, such as the Mediterranean diet Engaging in challenging or brain-stimulating leisure activities like doing Sudoku or completing word puzzles Limiting alcohol intake Socializing with others Summary While people often don't start worrying about brain health until they are older, studies such as those mentioned above demonstrate that maintaining the brain's well-being needs to start when we are much younger. This means making good choices now. Not all brain shrinkage is preventable, but getting regular exercise and controlling blood pressure may help. So too can other lifestyle changes, giving us several things we can do today to help protect against age-related brain atrophy tomorrow. Strategies to Boost Brain Health and Fight Aging 14 Sources Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Persson N, Ghisletta P, Dahle CL, et al. Regional brain shrinkage and change in cognitive performance over two years: The bidirectional influences of the brain and cognitive reserve factors. NeuroImage. 2016;126:15-26. doi:10.1016/j.neuroimage.2015.11.028 National Institute of Neurological Disorders and Stroke. Glossary of neurological terms. Bugiani O. Why is delirium more frequent in the elderly? Neurolog Sci. 2021;42:3491-3503. doi:10.1007/s10072-021-05339-3 Spartano NL, Himali JJ, Beiser AS, et al. Midlife exercise blood pressure, heart rate, and fitness relate to brain volume 2 decades later. Neurology. 2016;86(14):1313-1319. doi:10.1212/WNL.0000000000002415 Zhu N, Jacobs DR, Schreiner PJ, et al. Cardiorespiratory fitness and cognitive function in middle age: The CARDIA study. Neurology. 2014;82(15):1339-46. doi:10.1212/WNL.0000000000000310 Christie GJ, Hamilton T, Manor BD, et al. Do lifestyle activities protect against cognitive decline in aging? A review. Front Aging Neurosci. 2017;9:381. doi:10.3389/fnagi.2017.00381 U.S. Department of Health and Human Services. Physical Activity Guidelines for Americans, 2nd edition. Mandolesi L, Polverino A, Montuori S, et al. Effects of physical exercise on cognitive functioning and wellbeing: biological and psychological benefits. Front Psychol. 2018;9:509. doi:10.3389/fpsyg.2018.00509 American Heart Association. Changes you can make to manage high blood pressure. Durazzo TC, Meyerhoff DJ, Yoder KK, Murray DE. Cigarette smoking is associated with amplified age-related volume loss in subcortical brain regions. Drug Alcoh Depend. 2017;177:228-236. doi:10.1016/j.drugalcdep.2017.04.012 Valls-Pedret C, Sala-Vila A, Serra-Mir M, et al. Mediterranean diet and age-related cognitive decline. JAMA Intern Med. 2015;175(7):1094-11-3. doi:10.1001/jamainternmed.2015.1668 Ferreira N, Owen A, Mohgan A, Corbett A, Ballard C. Associations between cognitively stimulating leisure activities, cognitive function and age-related cognitive decline. Int J Geriatr Psychiatry. 2014;30(4):422-430. doi:10.1002/gps.4155 Toledo Nunes P, Kpp BT, Reitz NL, Savage LM. Chapter four - Aging with alcohol-related brain damage: Critical brain circuits associated with cognitive dysfunction. Int Rev Neurobiol. 2019;148:101-168. doi:10.1016/bs.irn.2019.09.002 Dause TJ, Kirby ED. Aging gracefully: social engagement joins exercise and enrichment as a key lifestyle factor in resistance to age-related cognitive decline. Neural Regen Res. 2019;14(1):39-42. doi:10.4103/1673-5374.243698 Additional Reading Spartano NL, Himalie JJ, Beiser AS, DeCarli C, Vasan RS, Seshadri S. Relations of midlife exercise blood pressure, heart rate and fitness to late life brain structure and function. Circulation. 2015;131(1):A13. doi;10.1161/circ.131.suppl_1.13 By Kendra Cherry, MSEd Kendra Cherry, MS, is a psychosocial rehabilitation specialist, psychology educator, and author of the "Everything Psychology Book." See Our Editorial Process Meet Our Review Board Share Feedback Was this page helpful? Thanks for your feedback! What is your feedback? Helpful Report an Error Other Submit